General description

A blood brain barrier permeable pyrimidinyl-aminothiazole compound that specifically interacts with TACC3 (transforming acidic coiledcoil-containing protein 3) and promotes nuclear localization of ARNT2 (aryl-hydrocarbon receptor nuclear translocator 2). Shown to significantly induce neuronal differentiation of cultured rat hippocampal NPCs (neural progenitor cells; EC₅₀ ~ 1 µM) and in adult rats (6 mg/kg, s.c.) and suppress proliferation.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Wurdak, H., et al. 2010. Proc. Natl. Acad. Sci. USA107, 16542

Packaging

Packaged under inert gas

10 mg in Glass bottle

Warning

Toxicity: Standard Handling (A)